“Plan de seguridad industrial para el control y prevención de siniestros en la empresa Procomsac-Chiclayo 2016”

Las empresas como parte de su desarrollo integral deben considerar dentro de su gestión los aspectos de control y prevención de siniestros, que ayuden a mantener el bienestar del Talento humano Esta tesis se basa en el desarrollo de un plan de seguridad industrial para el control y prevención de siniestros, que incluye prevención de riesgos laborales, teniendo como principal objetivo brindar una protección adecuada a los trabajadores de la empresa. Dicha investigación muestra los resultados del trabajo realizado en la empresa PROCOMSAC-Chiclayo 2016, empezando por realizar un diagnóstico de la situación actual de la misma, para luego diseñar el plan aplicable a toda la organización, basada en la prevención de siniestro

Las capas de "Bulimus" gerundensis Vidal, de la región de Utiel (Valencia)

Se da cuenta de nuevos hallazgos del Bulimus gerundensis, en la región de Utiel, estudiándose su situación estratigráfica, su relación con el Microcodium y su posible utilización paleogeogrifica

Dissecting a vegetable landrace: Components of variation in Spanish ?Moruno? tomatoes as a case studio

The variability of landraces is dissected and related to farmers' practices through surveys. Spanish 'Moruno' tomatoes, recognised for their excellent flavour, were selected as a case study. For this purpose, 30 populations were characterised in a four-year program. Higher intra-population than inter-population variability was found. Variability is generally reduced in the traits used by farmers as selection criteria. Farmers rarely used flavour as a selection criterion, but it is one of the main characteristics used by them to define the landrace. Seed exchange and growing different landraces simultaneously are commonplace, and outcrossing might occur, thus justifying in part the seed degeneration problems experienced by some farmers. At the same time, farmers select seeds for the next year on a per-fruit basis rather than a per-plant basis, justifying the maintenance of a high level of variability. In such cases, high pressure would be applied to key morphological traits but not to flavour. Accordingly, the sugars, acids and volatiles profiles related to flavour in the landraces' populations are highly variable, though the environment also exercises a high effect. It is necessary to make population selections to offer farmers materials combining the best organoleptic perception and a high stable yield. This would reduce the gap between the price premium received by farmers and the expected fair price. It would also be necessary to develop consumer information campaigns to exploit their willingness to pay for the extra value offered by landraces. Only then long-term on-farm conservation would be economically feasible. Although achieving a trade-off between yield and flavour is difficult, it is possible to identify populations that reach a compromise between them. In germplasm banks, it is impossible to evaluate all the materials in the same year. The use of hybrid controls, with no genetic variation, is helpful in considering the environmental effects. Still, genotype x environment interactions are evident, and using selected control populations of landraces is necessary to evaluate possible performances closer to the type of materials being evaluated

Soluble factors from Lactobacillus reuteri CRL1098 have anti-inflammatory effects in acute lung injury induced by lipopolysaccharide in mice

We have previously demonstrated that Lactobacillus reuteri CRL1098 soluble factors were able to reduce TNF-a production by human peripheral blood mononuclear cells. The aims of this study were to determine whether L. reuteri CRL1098 soluble factors were able to modulate in vitro the inflammatory response triggered by LPS in murine macrophages, to gain insight into the molecular mechanisms involved in the immunoregulatory effect, and to evaluate in vivo its capacity to exert antiinflammatory actions in acute lung injury induced by LPS in mice. In vitro assays demonstrated that L. reuteri CRL1098 soluble factors significantly reduced the production of pro-inflammatory mediators (NO, COX-2, and Hsp70) and proinflammatory cytokines (TNF-a, and IL-6) caused by the stimulation of macrophages with LPS. NF-kB and PI3K inhibition by L. reuteri CRL1098 soluble factors contributed to these inhibitory effects. Inhibition of PI3K/Akt pathway and the diminished expression of CD14 could be involved in the immunoregulatory effect. In addition, our in vivo data proved that the PS induced secretion of the pro-inflammatory cytokines, inflammatory cells recruitment to the airways and inflammatory lung tissue damage were reduced in L. reuteri CRL1098 soluble factors treated mice, providing a new way to reduce excessive pulmonary inflammation.Fil: Griet, Milagros. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); ArgentinaFil: Zelaya, María Hortensia del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); ArgentinaFil: Mateos, Melina Valeria. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaFil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); ArgentinaFil: Juarez, Guillermo Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); ArgentinaFil: Font, Graciela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); ArgentinaFil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); ArgentinaFil: Salvador, Gabriela Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaFil: Rodriguez, Ana Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentin

Mussel as a Tool to Define Continental Watershed Quality

Bivalves appear as relevant sentinel species in aquatic ecotoxicology and water quality assessment. This is particularly true in marine ecosystems. In fact, several biomonitoring frameworks in the world used mollusks since several decades on the base of contaminant accumulation (Mussel Watch, ROCCH) and/or biological responses called biomarker (OSPAR) measurements. In freshwater systems, zebra and quagga mussels could represent alternative sentinels, which could be seen as the counterparts of mussel marine species. This chapter presents original studies and projects underlying the interest of these freshwater mussels for water quality monitoring based on contaminant accumulation and biomarker development measurements. These sentinel species could be used as a tool for chemical/biological monitoring of biota under the European water framework directive and for the development of effect-based monitoring tools

Instrucciones para planificar la actividad docente de una asignatura: la guía docente y la programación temporal

La planificación de detalle que realiza el profesorado de una determinada asignatura se recoge en dos documentos distintos: la guía docente y la programación temporal. La información incluida en ellos será de utilidad para los estudiantes que cursen la asignatura pero no solo para ellos, ya que se empleará también como base para la coordinación docente y en los procesos de revisión y seguimiento de los títulos. Este libro está concebido para servir de apoyo al profesorado a la hora de planificar su docencia y cumplimentar los dos documentos citados

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states

Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer’s disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the shape of cortical regions. However, ‘shape connections’ between brain regions are rarely investigated -e.g., how morphological attributes such as cortical thickness and sulcal depth of a specific brain region change in relation to morphological attributes in other regions. To fill this gap, we unprecedentedly design morphological brain multiplexes for late MCI/AD classification. Specifically, we use structural T1-w MRI to define morphological brain networks, each quantifying similarity in morphology between different cortical regions for a specific cortical attribute. Then, we define a brain multiplex where each intra-layer represents the morphological connectivity network of a specific cortical attribute, and each inter-layer encodes the similarity between two consecutive intra-layers. A significant performance gain is achieved when using the multiplex architecture in comparison to other conventional network analysis architectures. We also leverage this architecture to discover morphological connectional biomarkers fingerprinting the difference between late MCI and AD stages, which included the right entorhinal cortex and right caudal middle frontal gyrus

Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease where biomarkers for disease based on pathophysiology may be able to provide objective measures for disease diagnosis and staging. Neuroimaging scans acquired from MRI and metabolism images obtained by FDG-PET provide in-vivo measurements of structure and function (glucose metabolism) in a living brain. It is hypothesized that combining multiple different image modalities providing complementary information could help improve early diagnosis of AD. In this paper, we propose a novel deep-learning-based framework to discriminate individuals with AD utilizing a multimodal and multiscale deep neural network. Our method delivers 82.4% accuracy in identifying the individuals with mild cognitive impairment (MCI) who will convert to AD at 3 years prior to conversion (86.4% combined accuracy for conversion within 1–3 years), a 94.23% sensitivity in classifying individuals with clinical diagnosis of probable AD, and a 86.3% specificity in classifying non-demented controls improving upon results in published literature